The World Health Organisation has called for "drastic action" to fight the deadliest Ebola outbreak on record, as it announced an 11-nation meeting to address the growing crisis.
As of Sunday, 635 cases of haemorrhagic fever (most confirmed to be Ebola), including 399 deaths, have been reported across Guinea, Liberia and Sierra Leone, making the outbreak the largest ever "in terms of the number of cases and deaths as well as geographical spread," WHO said.
"Drastic action is needed," the UN agency stressed in a statement, warning of the danger that the virus could jump to other countries.
Earlier this week, medical charity Doctors Without Borders (MSF) also said the outbreak of the virus, which is deadly in up to 90 per cent of cases, was "out of control".
Since west Africa's first-ever epidemic of the deadly haemorrhagic fever emerged in Guinea in March, the organisation has sent in more than 150 experts to help tackle the crisis.
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Despite the efforts of the WHO and others, there has been a "significant increase" in the number of cases and deaths reported each day for the past three weeks, it said.
The agency is now "gravely concerned (by) the on-going cross-border transmission into neighbouring countries as well as the potential for further international spread," said WHO's regional director for Africa, Dr Luis Sambo.
"This is no longer a country specific outbreak, but a sub-regional crisis that requires firm action by governments and partners," he warned.
WHO's top Ebola specialist Pierre Formenty told AFP last week the recent surge in cases had come in part because efforts to contain the virus had been relaxed too quickly after the outbreak appeared to slow down in April.
To address the growing crisis, the WHO said Thursday it would convene a meeting of the health ministers from 11 countries in Accra, Ghana on July 2 and 3 "to discuss the best way of tackling the crisis collectively as well as develop a comprehensive inter-country operational response plan."
No medicine or vaccine exists for Ebola, which is named after a small river in the DRC.
