"Mamadou Sakho had an operation in Paris yesterday and will need time to recover. We hope to get him back as soon as we can," Hodgson told a news conference.
Defender Aaron Wan-Bissaka has shaken off a hamstring injury and is available while Pape Souare is also making progress after dislocating his shoulder.
"Wan-Bissaka is fit again, which is a boost for us. Souare is close to returning," Hodgson added.
"It's been a fantastic year for Aaron. I like how hard he works and how firmly he's been able to keep his feet on the ground. His consistency, work-rate and humility to learn and grow are all wonderful assets."
Palace are 14th in the table with 30 points from 28 matches.
(Reporting by Shrivathsa Sridhar in Bengaluru; Editing by Toby Davis)
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