Muscat told The World Game there were several main factors at play, headed by Berisha's ability to score goals in many different situations and not be a one-trick pony.
He said Berisha was constantly fouled but never allowed that treatment to put him off his game and that as much as he loved scoring goals, winning was still more important to him and was the reason he worked so hard for the team.
Berisha, who is in his third season at Victory after previously playing for Brisbane Roar, is on 89 A-League goals, one behind former Victory forward Archie Thompson's record mark as the Melbourne derby against City looms at AAMI Park on Saturday.
"Archie and 'Bes' have both set unbelievable standards in their time in the competition, unprecedented the pair of them," Muscat said.
"Obviously Archie retired at the end of last season and it's now inevitable Bes will get to that milestone and what better way would there be to do it than maybe this week.
"Bes has got an unbelievable knack of being in the right position at the right time and also he's not one-dimensional. He doesn't score the same goals all the time, as you saw against Wanderers last week.
"The first one was opportunistic, he followed up a blocked shot, the second one was him being between central defenders and not being marked and getting a header and the third one was in transition on the break and he got one-on-one with the 'keeper.
"The fact he's accomplished in all different goal-scoring situations gives him the opportunities he had in that game, but if you speak to Bes the first thing on his mind would be to win and that it's a bonus if it's him that scores.
"Ultimately it's a team victory that's paramount to him and he always works very hard for that."
City striker Bruno Fornaroli has had an enormous amount of publicity since he exploded on the A-League scene last season.
Asked if he thought Berisha might be even more motivated by the coverage Fornaroli gets, Muscat replied: "I'm not so sure. Bes gets on with his own game.
"One thing with Bes as well is that a lot gets said about other players and the treatment they cop, but he gets kicked from pillar to post and he's not one to go down easily. He always wants to stay up, so he doesn't get the fouls that he should."