Hundreds of thousands of people flock to the Uluru-Kata Tjuta National Park every year to take in the grandeur of a world heritage-listed icon.
The final climber will descend from the monolith on Friday, with the route officially closed to visitors from Saturday October 26th.
Since the climbing ban was announced two years ago, there has been a rush of tourists eager to climb the rock.
Uluru is a sacred place to many people.
Former Uluru-Kata Tjuta National Park Board Chair, Donald Fraser, says the closure of the climb is something Anangu traditional owners have long fought for.