A man, 36, was reportedly paying $30 a night to stay at the Brighton East home where he was allegedly raped and murdered on Wednesday night.
Three men were charged with his murder.
Craig Levy, 36, Ryan Smart, 37, and Jason Colton, 41, did not apply for bail when they faced the Melbourne Magistrates' Court on Friday.
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Levy and Smart were charged with murder, while Colton was charged with murder and also raping the victim with an object.
Airbnb said the victim's family had its full support and "our hearts go out to them and all of his friends".
"There is no place on Airbnb for such an abhorrent act, which violates everything our global community stands for," the company said in a statement.
"We have removed this listing from our platform and will fully co-operate with law enforcement on their investigation."
The cause of death is yet to be released, but police earlier said the man was in cardiac arrest and paramedics had tried to revive him.
The three accused will return to court on March 22.
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