AFL chief executive Gillon McLachlan hopes ASADA will not appeal against the anti-doping tribunal findings.
Earlier on Tuesday afternoon, the tribunal cleared 34 current and former Essendon players on charges relating to the club's supplements scandal.
It is a landmark moment in the saga, now into its third year.
Under the anti-doping process, ASADA and also its international parent body WADA can appeal the verdicts.
Asked if he would like to see an ASADA appeal, McLachlan said: "that's a decision for ASADA - my personal view is no.
"There's a decision that's been made after a long, protracted period."
The tribunal is yet to reach a verdict on former Essendon sports scientist Stephen Dank and McLachlan said this is expected after Easter.
McLachlan added the league was still reviewing the 133-page tribunal judgment.
The AFL wants the full details of the decision to be made public, but said this was up to the players.
While McLachlan was happy for the players and thanked them for how they handled the long investigation, the AFL remains critical of what happened at Essendon in 2012.
"I am pleased for the players and understand what a relief this is," he said.
"Judgment and evidence should give no-one any joy about what happened in our competition in 2012.
"It has the AFL's view and the view of Essendon's own internal report that the players were victims of a reckless program.
"Given the evidence the AFL collected, the ASADA interim report and Essendon's own report, it was clear that breaches of the AFL rules had occurred."
McLachlan also acknowledged that Essendon had worked hard since 2013 to improve their practices at the club.
There is ongoing and fierce criticism of how the AFL has handled the supplements saga, but McLachlan is unrepentant.
"I am extremely comfortable with the process in general," he said.
"I've been held to task for saying 'you'd do things differently' - I think in life, if you don't learn from decisions and instances and nuances ... everyone should be learning every day."
McLachlan said he stood by the raft of AFL sanctions on Essendon in August, 2013.
These related to governance issues.
McLachlan added the players had been through a lot in the last couple of years.
"I feel for the players over this long period of time - you could see the anguish on Jobe Watson's face today," he said.
"It's been a very difficult period for them.
"The players have had a terrible 26 months and I know they're looking forward to playing the game."
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