Ajax will go into the final round of fixtures on Wednesday with a three-point lead over PSV and 14 goals to the good on goal-difference as they travel to second-bottom De Graafschap. PSV are home to seventh-placed Heracles.
Klaas-Jan Huntelaar and Donny van de Beek also netted for Ajax as they put behind them the disappointment of their stoppage-time exit from the Champions League at the hands of Tottenham Hotspur this week.
Ajax will extend their record of Dutch title wins to 34 in a season in which they have scored 115 goals in their 33 league games and also claimed the Dutch Cup under manager Erik ten Hag.
Defending champions PSV paid a heavy price for some sloppy finishing as they lost 1-0 in Alkmaar to a Guus Til goal.
Robin van Persie ended his career at Feyenoord in Rotterdam but there was no fairytale finish as they were surprisingly beaten 2-0 at home by ADO Den Haag.
He did hit the woodwork with a first-half effort before going off to a massive ovation in stoppage time at the end of the game.
(Reporting By Nick Said and Mark Gleeson; Editing by Toby Davis and Tony Lawrence)
