An all-Australian quarter-final between Alex de Minaur and Jordan Thompson headlines a local-heavy fifth day of the Sydney International on Thursday.
The pair join Australian female No.1 Ashleigh Barty, who takes on Elise Mertens, and John Millman, who meets Gilles Simon, all vying for spots in the semi-finals.
Also in action will be world No.2 Angelique Kerber, who will continue her title defence against two-time Wimbledon champion Petra Kvitova in another mouthwatering affair.
But it will be the stoush between Davis Cup teammates de Minaur and Thompson that could have Ken Rosewall Arena split into two.
The 29th-ranked de Minaur recently won their first meeting on the senior tour in Brisbane, knocking the world No.72 out of the second round in straight sets.
The 15th-ranked Barty, who lost to Kerber in the final last year, faces off against the 12th-ranked Belgian in Mertens in what will be their first encounter.
Meanwhile, Millman, who stunned Roger Federer on his way to making his first grand slam quarter-final at last year's US Open, has the tough task of taking down fourth-seeded Simon.
The 38th-ranked Millman has never faced the former world No.6, but is backing himself in what is expected to be humid conditions.
"I have grown up in Brisbane, obviously it's normally quite humid, especially in the summers, and with that humidity, it's quite conducive to heavy conditions," Millman said.
"I always feel like can really hit out at the ball and really back my ball striking in those conditions and really swing through it.
"I'd much prefer heavier conditions than playing in the altitude, which I hate. Don't mind the heavy conditions. Whenever I play, though, I'm pretty comfortable here in Australia."
The 29-year-old Millman said Australians could have more success tour if more tournaments, particularly at the second-tier level, were staged on home soil.
"The more tournaments we can have and the more access we can have to our coaches back home, maybe limit the expenses a little bit, I think you'll find the more comfortable players are," he said.
"And then, you know, once you get up inside that top 100, things are a little easier.
"You have access to physio, better practice facilities, you're playing some bigger tournaments, so things are a little bit more comfortable."
