Armitage, the European player of the year, again demonstrated his excellence and power as he led the French side's eight-try rout.
Toulon's international 'galactico' lineup ran riot against the injury-hit former champions with try scorers from six different countries.
Englishman Armitage was joined on the scoresheet by Argentina's Nicolas Sanchez, South Africa's Bryan Habana, Frenchman Mathieu Bastareaud, Italian Martin Castrogiovanni and Georgian Mamuka Gorgodze. Welshman Leigh Halfpenny chipped in with 20 points with the boot.
Yet it was Armitage who again stole the show. In World Cup year, the back row forward's continued brilliance must be exercising the mind of England coach Stuart Lancaster, who does not consider him for selection because he is playing outside the country.
The victory means Toulon cannot be caught for top spot in Pool 3 and they have sealed a home tie in the last eight of the inaugural Champions Cup.
Last season, they won the Heineken Cup -- which has been replaced by the Champions Cup -- against Saracens who, despite beating Munster 33-10 at Allianz Park on Saturday, face an uphill task at Clermont Auvergne to guarantee a quarter-final spot.
Sarries had been desperate for a bonus point to enhance their last eight chances, especially with their final Pool 1 match being at the French giants next week.
Yet despite two tries by Chris Ashton and another from Chris Wyles before halftime, and although inspired by a towering performance from Billy Vunipola, they fell just short.
Clermont, with a hard-earned 22-13 win at Sale Sharks, sealed by a try from Samoan Fritz Lee, are in pole position, a point clear of Saracens as they go into next Sunday's showdown which will ensure a last eight berth for the victors.
Another winner-takes-all clash is set for the Ricoh Stadium where twice European champions Wasps, inspired to a 23-3 win at Harlequins by James Haskell's man of the match performance, will play three-time winners Leinster.
The Irish side lead Pool 2 by two points after hammering visiting Castres 50-8 with seven tries but top spot will only be decided in the clash at Wasps' new Coventry home next Saturday.
(Writing by Ian Chadband; Editing by Ken Ferris)
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