The London rivals have met three times in the competition in the last 10 years with Arsenal winning a two-legged 2007 semi-final and Spurs triumphing at the same stage the next season. Arsenal won after extra time in the third round in 2010.
Another enticing derby sees five-time champions Aston Villa facing second-tier Birmingham City in a second city derby.
Holders and premier League champions Chelsea, who beat four-times winners Spurs 2-0 at Wembley in last season's final, start the defence of their trophy with a trip to third-tier Walsall.
As well as the north London derby, other all Premier-League ties see Sunderland hosting leaders Manchester City, Norwich City welcoming West Bromwich Albion and Leicester City entertaining West Ham United.
Record eight-times winners Liverpool will play basement division side Carlisle United at Anfield, while Manchester United take on second-tier Ipswich Town at Old Trafford.
Ties will be played during the week of Sept. 21.
(Writing by Ken Ferris; Editing by Greg Stutchbury)
