Australia were on the brink of victory having reduced England, who needed 561 for an unlikely victory, from 142 for four to 160 for eight after the initial 90-minute weather delay, which incorporated the tea break.
More than 42 overs of play were scheduled for the remainder of the day, although they look highly unlikely to be completed, and there will be an early start on day five.
England's Joe Root was 15 not out when the umpires called the players off for the second time with tailender Chris Tremlett on one.
Australia are looking for a first victory in 10 tests as they bid to prevent England from winning a fourth successive Ashes series.
(Reporting by Nick Mulvenney; Editing by Amlan Chakraborty)
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