AstraZeneca coronavirus vaccine could be up to 90 per cent effective, results show

AstraZeneca has become the latest pharmaceutical company to unveil positive interim data in the global race for a coronavirus vaccine and says it's looking to produce up to three billion doses in 2021.

AstraZeneca is likely to run an additional trial of its coronavirus vaccine.

AstraZeneca is likely to run an additional trial of its coronavirus vaccine. Source: AP

Federal Health Minister Greg Hunt said the Oxford-AstraZeneca vaccine results will allow for a "fully safe Australia".

Speaking on the back of the results earlier this morning, Mr Hunt said the vaccine could be available in Australia by March.

He said the development signified a pathway to "not just a COVID-safe Australia, but a fully-safe Australia - a return to normal".

The federal government has committed to buying 33.8 million doses of the vaccine, with healthcare workers and the elderly able to receive them at the highest priority.

British drugs group AstraZeneca and the University of Oxford say their jointly-developed vaccine against COVID-19 has shown "an average efficacy of 70 per cent" in trials.

"This vaccine's efficacy and safety confirm that it will be highly effective against COVID-19 and will have an immediate impact on this public health emergency," AstraZeneca chief executive Pascal Soriot said in a statement.

The results ranged between 62 and 90 per cent efficacy depending on the vaccine dosage.

The 70-per cent average is lower compared with the efficacy of coronavirus vaccines trialed by rivals Pfizer/BioNTech and Moderna which have come in above 90 per cent.

Monday's statement said "positive high-level results from an interim analysis of clinical trials of AZD1222 in the UK and Brazil showed the vaccine was highly effective in preventing COVID-19... and no hospitalisations or severe cases of the disease were reported in participants." 

It added: "One dosing regimen (n=2,741) showed vaccine efficacy of 90 per cent when AZD1222 was given as a half dose, followed by a full dose at least one month apart."

The pair said that regimen n=8,895 showed 62 per cent efficacy when given as two full doses at least one month apart.

"The combined analysis from both dosing regimens (n=11,636) resulted in an average efficacy of 70 per cent."

AstraZeneca said it would "immediately prepare regulatory submission of the data to authorities around the world that have a framework in place for conditional or early approval". 

It added that it would seek emergency-use listing from the World Health Organization to accelerate vaccine availability in low-income countries.

The AstraZeneca factory in Dunkirk, northern France.
AstraZeneca says its vaccine for the novel coronavirus, developed along with the University of Oxford, showed an average efficiency of 70 per cent. Source: ABACA

AstraZeneca said it is looking at a capacity of up to three billion doses of the vaccine in 2021 pending regulatory approval. 

It said the vaccine can be stored, transported and handled "at normal refrigerated conditions" of between two and eight degrees Celsius for at least six months.

'Save many lives'

More than 23,000 adults are currently being assessed in the trials, with the number expected to rise to up to 60,000, the statement said.

"Clinical trials are also being conducted in the US, Japan, Russia, South Africa, Kenya and Latin America with planned trials in other European and Asian countries," it added.

Oxford professor Andrew Pollard said the latest findings show "an effective vaccine that will save many lives". 

"Excitingly, we've found that one of our dosing regimens may be around 90 per cent effective and if this dosing regime is used, more people could be vaccinated with planned vaccine supply. 

"Today's announcement is only possible thanks to the many  volunteers in our trial, and the  hard working and talented team  of researchers based around the world," added Prof Pollard, who is chief investigator of the Oxford Vaccine Trial.

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4 min read
Published 23 November 2020 at 7:45pm
Source: AFP, SBS