Aust study tracks down 'obesity gene'

Australian researchers believe a previously unrecognised gene believed to be responsible for obesity could change the way type two diabetes is treated.

Obesity and type 2 diabetes sufferers are often told the same thing: overeating and a sedentary lifestyle are the main causes of their condition.

However, Australian researchers believe a previously unrecognised gene thought to be responsible for obesity could finally prove the cause and treatment of these conditions is far more complex.

Researcher Doctor Sof Andrikopoulos said the study used specially bred mice from eight different genetic backgrounds to measure body weight, blood glucose and insulin sensitivity before isolating key genes through a process of gene mapping.

The research has found several genes responsible for metabolic disorders that shows many genetic factors predispose people to diabetes and obesity.

"We need to stop oversimplifying type 2 diabetes as a condition caused by excessive weight and a sedentary lifestyle," Dr Andrikopoulos said.

He expects it could take several years before the researchers can identify the holy grail - the "obesity gene" - and introduce better treatment.

However, Dr Andrikopoulos said it would be worth the wait considering obesity was associated with so many other diseases, including cardiovascular disorders and cancer.

"If we can effectively treat obesity, then all the other associated conditions are getting treated, so that's very important," he said.

The research, by Melbourne University and Professor Harry Perkins Medical Research Institute in Perth, will be discussed on Wednesday at the largest gathering of diabetes experts in Australia in Melbourne.

SOME FACTS ABOUT DIABETES

* Diabetes is Australia's fastest-growing chronic disease.

* 1.1 million Australians have diabetes.

* About 90 per cent have type 2 diabetes.

* There is no cure for diabetes, but it can be managed.


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