He has not appeared for Spurs this season, and was pictured in Spain over the weekend. He missed Wales's recent friendly against Ireland due to a foot problem that has troubled him since July.
Aaron Ramsey has also been named in the squad, despite leaving the pitch with a groin injury after scoring both of Arsenal's goals in a 2-0 Champions League play-off victory over Fenerbahce on Wednesday.
Wales, who are 13 points behind Group A leaders Belgium and 10 off second-placed Croatia, play Macedonia in Skopje on September 6, followed by Serbia in Cardiff on September 10.
(Reporting by Josh Reich, editing by Alan Baldwin)
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