Australian No.1 Ashleigh Barty and compatriot John Millman have booked their places in Eastbourne quarter-finals after straight-sets victories.
Barty will face world No.2 Caroline Wozniacki after a quick third-round victory over Taiwan's Hsieh Su-Wei in East Sussex on Wednesday.
She deployed her strong first serve and formidable forehand play to defeat Su-Wei 6-0 6-4 in 74 minutes.
Top seeded Dane Wozniacki earlier eliminated British No.1 Johanna Konta 4-6 6-1 6-4.
Fellow Australian John Millman also made it through to the final eight after defeating Argentine Leonardo Mayer in a double tiebreak match that ended 7-6 (9-7) 7-6 (7-4).
The 29-year-old will meet fourth-seeded Italian Marco Cecchinato in the quarter-finals.
Meanwhile, former world No.1 Andy Murray tumbled out of the tournament after a straight-sets loss to British compatriot Kyle Edmund.
Edmund's rise to 18th in the rankings has coincided with Murray's year out with a hip injury which has seen him drop to 156th in the world.
The 23-year-old Edmund admitted it had been a "weird" feeling taking on his Davis Cup teammate and the man who had mentored him in his early days on the ATP Tour.
Murray, playing only his third match back as he tries to prove his fitness for Wimbledon, made things awkward and fought tenaciously but had no answer to Edmund's ferocious forehand.
He became the first British player to beat Murray for 12 years.
"It was a bit of a tough match, mentally, playing Andy but I had to try to view it as another match," second seed Edmund, who will play Kazakhstan's Mikhail Kukushkin next, said on court.
"I've looked up to Andy so much and he's looked after me and really been good for me so it's a bit of a weird feeling. I was a bit nervous towards the end."
Fourth seed Angelique Kerber thrashed American Danielle Collins 6-1 6-1 to set up a clash with seventh seed Daria Kasatkina, who defeated Anastasija Sevastova 6-4 6-4.
Fifth seed Jelena Ostapenko overpowered Romanian Mihaela Buzarnescu 6-1 6-2 and will face Poland's Agnieszka Radwanska, who was given a walkover by former Wimbledon champion Petra Kvitova, after the third seed withdrew with a hamstring injury.
Meanwhile, men's top seed Diego Schwartzman lost 4-6 6-4 7-5 to Slovakian Lukas Lacko but third seed Canadian Denis Shapovalov beat Jared Donaldson 6-4 4-6 6-2.
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