Top seed Roberto Bautista Agut eased into the quarter-finals of the Winston-Salem Open, beating Marcos Baghdatis 6-3 6-4.
The Spaniard's win sets up a last-eight meeting with Taylor Fritz.
Fritz, who received a wild card for the final tournament before the US Open, continued his run with 7-6 (7-3) 7-6 (7-5) win over Paolo Lorenzi.
Fellow American and third seed John Isner was sent packing, though, in a surprise straight sets defeat to Borna Coric. The Croatian, who beat Andy Murray in Madrid earlier this summer, won 7-5 6-2.
Steve Johnson will meet Kyle Edmund in the last eight after he beat Carlos Berlocq 7-6 (7-1) 6-4, with Edmund seeing off Marton Fucsovics 6-2 6-1.
Berlocq had previously beaten Australian qualifier Alex Bolt in straight sets.
The 24-year-old Bolt, ranked No.301 in the world, was the only Australian in the main draw of the ATP tournament after coming through two rounds of qualifying.
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