On Thursday, Belgium beat South Korea 1-0 to top Group H, setting up a clash with the United States after Juergen Klinsmann's team pipped Portugal to second place in Group G on goal difference despite losing to Germany.
"Hey @BarackObama, I am betting some great Belgian beers that our @BelRedDevils will make it to the quarter final!" Di Rupo tweeted in the early hours of Friday.
As of Friday morning, the U.S. President had not replied to the challenge.
He may be well advised to abstain from such a bet, as Belgium are the bookies favourites going in to last 16 match on Tuesday.
Obama should also be warned that a large number of Belgian beers have a very high alcohol content. It was not clear precisely what beers Di Rupo was offering in the bet.
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