Dan Biggar will start at five-eighth for Wales as they look to finish second in the Six Nations when they host France at the Millennium Stadium on Saturday.
Biggar will resume his partnership with scrumhalf Gareth Davies having sat out the 38-14 victory over Italy in the previous fixture.
They will form part of backline that also includes Hadleigh Parkes and Scott Williams as the centre-pairing, and Liam Williams, George North and Leigh Halfpenny forming an all British and Irish Lions back-three.
There had been some suggestion in the build-up that Gareth Anscombe would continue in the number 10 jersey, but Kiwi coach Warren Gatland has gone for the greater experience of Biggar.
"There have been some tough selection calls, but that is exactly what we want, we want to be in a position where there are selections and decisions to be made and we have had to make some tough ones this weekend," said Gatland, whose side are second in the standings.
There was also much change in the pack as lock and captain Alun Wyn Jones returns to the side, along with prop Rob Evans, hooker Ken Owens and flank Josh Navidi.
"Saturday is a huge opportunity for us to finish the campaign well, at home in front of our fans," Gatland said.
"France will be coming to Cardiff in good spirits after their victory over England last weekend so it is set to be a huge encounter."
Wales Team: Leigh Halfpenny, George North, Scott Williams, Hadleigh Parkes, Liam Williams, Dan Biggar, Gareth Davies, Taulupe Faletau, Josh Navidi, Justin Tipuric, Alun Wyn Jones (captain), Cory Hill, Tomas Francis, Ken Owens, Rob Evans.
Replacements: Elliot Dee, Nicky Smith, Samson Lee, Bradley Davies, Aaron Shingler, Aled Davies, Gareth Anscombe, Steff Evans.
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