The Cofidis rider finished ahead of Davide Cimolai and Daryl Impey.
BMC rider Van Garderen finished safely in the pack to retain his 41-second advantage ahead of Friday's fifth stage which features a 1,000 metre climb towards the finish in Lo Port.
Team mate Samuel Sanchez is his closest challenger with Team Sky's Geraint Thomas a further three seconds back. Spain's Alberto Contador is seventh, one minute 13 seconds in arrears.
Tour de France champion Chris Froome, Alejandro Valverde and his Movistar team mate Marco Soler attacked near the summit of the second-category Tudo del Puig on Thursday and managed to open a small gap before being caught with five kilometres left.
(Writing by Martyn Herman; Editing by Toby Davis)
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