A Court of Arbitration for Sport hearing for the Essendon supplements scandal will begin on November 16 in Sydney.
CAS says the case, involving 34 current and former Essendon players, is expected to last between five and seven days.
The hearing shapes as the longest conducted by CAS in recent years.
A verdict would typically follow weeks later.
The World Anti-Doping Agency has appealed an AFL ruling not to sanction players accused of using a banned peptide in 2012.
Players were allegedly injected with the banned substance, Thymosin Beta-4, at the suggestion of a sports scientist.
The AFL banned Essendon from the 2013 playoffs during the initial investigation.
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