Chelsea have endured more Stamford Bridge frustration as Southampton held the Premier League leaders to a 1-1 draw, while Wayne Rooney delivered the knockout blow in Manchester United's 3-0 win against Tottenham.
Jose Mourinho's side would have moved eight points clear of second placed Manchester City if they had beaten Southampton, but instead they had to settle for a share of the spoils in west London.
Diego Costa's 11th minute header had ended the Spain striker's seven-match goal drought.
Yet Chelsea failed to press home their advantage and Southampton equalised eight minutes later when Dusan Tadic converted a penalty awarded for a Nemanja Matic foul on Sadio Mane.
The Blues laid siege to the Southampton goal in the closing stages, but Oscar, Juan Cuadrado and John Terry all wasted chances to seal a victory that would have left them well on course to win the English title for the first time since 2010.
The frustrating result came just days after Chelsea crashed out of the Champions League on away goals following a 2-2 draw against Paris Saint Germain in front of their own supporters.
Chelsea have now drawn their past three home matches in all competitions, but Mourinho was still relatively happy to see his side move six points clear of City, who were surprisingly beaten by struggling Burnley on Saturday.
"I agree Chelsea not winning at home is not a good result," he said.
"But yesterday we had five points more than City, now we have six points more and one (extra) match to play.
"It makes our situation better than before the game. It's positive rather than negative.
"The performance was not amazing, but we created more stability than we had in the last matches."
At Old Trafford, Rooney was firmly in the spotlight as fourth-placed United produced a rare heavyweight display in a spluttering campaign to move within one point of third-placed Arsenal.
Louis van Gaal's side made the perfect start as they took the lead in the ninth minute when Marouane Fellaini, played in by Michael Carrick's fine pass, kept his composure to beat Tottenham goalkeeper Hugo Lloris with a low left-footed shot.
Carrick went from provider to scorer 10 minutes later when United's former Tottenham midfielder looped a header past Lloris after Fellaini's initial effort had only been half cleared.
Rooney ensured the match would be remembered mostly for his contribution in the 34th minute.
Earlier on Sunday, video footage emerged of Rooney being knocked out by Stoke defender Phil Bardsley during a supposedly friendly sparring session, with both men wearing boxing gloves, in the England striker's kitchen last month.
And Rooney seized the opportunity to poke fun at himself after he rampaged through the Tottenham defence to fire home following Nabil Bentaleb's mistake.
With all eyes on him, Rooney celebrated by miming a series of punches and then falling onto his back as if knocked out.
Elsewhere, Everton eased their relegation fears with a 3-0 stroll against Newcastle at Goodison Park.
On Monday, fifth placed Liverpool, five points behind Manchester United, will look to bolster their challenge for a top four finish when they travel to Swansea.
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