Patrick Mahomes and the Kansas City Chiefs have improved their NFL record to 5-0 with a 30-14 victory over the Jacksonville Jaguars.
Mahomes had his first interception of the season but threw for 313 yards and rushed for a touchdown of his own.
The Chiefs raced into a 23-0 lead before Jaguars quarterback Blake Bortles overcame a terrible first half to throw for one touchdown and rush for another.
Los Angeles Rams maintained their 100 per cent record after prevailing in a tight contest with the Seattle Seahawks 33-31.
The lead change five times with neither side ever leading by more than seven points, with the score locked at 17-17 at halftime.
Cairo Santos was true with the boot on a 39-yard field goal attempt with 6:09min left in the game and the Rams defence held strong for the win.
Cincinnati Bengals improved to 4-1 with a come-from-behind 27-17 win against the Miami Dolphins.
Miami led 17-0 in the third quarter but the Bengals scored 27 unanswered points - 24 in the fourth quarter.
Baltimore Ravens were beaten 12-9 by divisional rivals the Cleveland Browns in overtime.
Cleveland kicker Greg Joseph missed a 55-yard field goal at the end of regulation but took his second match-winning opportunity as he sunk an effort from 37 yards to secure the Browns' second victory of the season.
Ben Roethlisberger threw for 250 yards and three touchdowns, two to Antonio Brown, while James Conner rushed for another two scores as the Pittsburgh Steelers recorded a 41-17 won over the Atlanta Falcons.
Graham Gano landed a 63-yard field goal with the last kick to secure the Carolina Panthers a thrilling 33-31 victory over the New York Giants.
The Giants took the lead late on through Saquon Barkley's second touchdown of the game - the first coming from a 57-yard throw from the unlikely source of wide receiver Odell Beckham Jr.
Quarterback Kirk Cousins was 30 of 37 for 301 yards and one touchdown to lead the visiting Minnesota Vikings past the Philadelphia Eagles 23-21.
Wide receiver Adam Thielen had 116 yards receiving and a touchdown for his fifth-straight 100-yard receiving game to open the season, becoming the first receiver since the 1970 AFL-NFL merger to achieve the feat.
Philip Rivers passed for 339 yards and two touchdowns to lead the Los Angeles Chargers to a 26-10 victory over the visiting Oakland Raiders.
New York Jets rookie quarterback Sam Darnold threw for three touchdowns to end his side's three-match losing run with a 34-16 victory against the Denver Broncos.
Stephen Hauschka scored a last-second field goal to give the Buffalo Bills a 13-12 win against the Tennessee Titans, Green Bay kicker Mason Crosby missed five of his six attempts as the Packers were beaten 31-23 by the Detroit Lions and the Arizona Cardinals recorded a 28-18.win over the San Francisco 49ers.
