Manchester City will have the chance to atone for last year's FA Cup final defeat by Wigan Athletic after being drawn against the holders in Sunday's quarter-final draw.
Wigan, now in the second tier Championship and managed by former City striker Uwe Rosler, will travel to Eastlands where Manuel Pellegrini's men beat Premier League title rivals Chelsea 2-0 on Saturday.
Wigan will be looking to claim another top flight scalp after beating Cardiff in the fifth round.
Elsewhere in the last eight Arsenal will face Everton at the Emirates Stadium after a 2-1 win at home to the Toffees' local rivals Liverpool in Sunday's late kick-off tie.
Earlier on Sunday, Everton advanced into the quarter-finals with a 3-1 win over Swansea.
There may be no Merseyside derby in this season's FA Cup but a 'Steel City' derby remains a possibility.
Third-tier Sheffield United, the lowest-ranked team left in the competition beat Nottingham Forest 3-1 on Sunday and they will now face Sheffield on Wednesday provided their arch-rivals defeat Charlton Athletic in a fixture originally postponed because of a waterlogged pitch.
Sunderland manager Gus Poyet could return to his former club Brighton provided the Seagulls defeat Hull on Monday.
The sixth round ties will be played on the weekend of March 8-9.
QUARTER-FINAL DRAW:
Arsenal v Everton
Brighton and Hove Albion or Hull City v Sunderland
Sheffield United v Sheffield Wednesday or Charlton Athletic
Manchester City v Wigan Athletic
