The hard-running rake suffered the latest in a long string of concussions in the New South Wales Waratahs's win over the ACT Brumbies in Canberra on May 1 and has not played since.
Michael Cheika, both Waratahs and Australia coach this year, said the 29-year-old would not play against Canterbury Crusaders this weekend or on the two-match tour of South Africa that follows the 2014 Super Rugby final re-match.
"There is no point in taking him to South Africa and having doubts over him," Cheika told reporters on Tuesday.
"We'll let him have a few weeks off and get sorted out and he can start again when we come back from South Africa."
The reigning champion Waratahs will only have one more match this season after the South Africa trip, against Queensland Reds in Sydney, if they fail to qualify for the playoffs.
Polota-Nau has won 50 caps for Australia despite an injury-prone career and, if fit, would be a certainty to go the World Cup later this year.
ACT Brumbies hooker Stephen Moore is a strong candidate to skipper the team but Cheika puts great stock in his bench and the ability to inject strong ball-runners like Polota-Nau in the second half will be key to his strategy in England.
Polota-Nau, whose distinctive "head-first" style of running and tackling must have contributed to the number of concussions he has suffered over his career, has been working with Australian neurologists on the effects of head damage in sport.
(Reporting by Nick Mulvenney; Editing by John O'Brien)
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