Ardron, who plays his club rugby for Ospreys in Wales, has failed to shake off a knee injury, the team said on Thursday.
Cudmore, 37, is featuring in a fourth World Cup, equalling the team record.
The Canucks have named their oldest starting line-up for a World Cup match with an average age of 29 years and 164 days.
Canada: 15-Matt Evans, 14-Jeff Hassler, 13-Ciaran Hearn, 12-Nick Blevins, 11-DTH Van Der Merwe, 10-Nathan Hirayama, 9-Gordon McRorie, 8-Aaron Carpenter, 7-John Moonlight, 6-Kyle Gilmour, 5 Jamie Cudmore (captain) 4-Brett Beukeboom, 3-Doug Wooldridge, 2-Ray Barkwill, 1-Hubert Buydens
Replacements: 16-Benoit Piffero, 17-Djustics Sears-Duru, 18-Andrew Tiedemann, 19-Jebb Sinclair, 20-Richard Thorpe, 21-Phil Mack, 22-Liam Underwood, 23-Conor Trainor
(Writing by Justin Palmer; editing by Clare Lovell)
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