"After a bad evening and night due to stomach problems I won't be able to start today's stage. Completely empty," Kruijswijk wrote on his Twitter feed before the start of the 20th and penultimate stage.
Kruijswijk was 10th in the overall standings after losing two spots in the 19th stage on Friday.
Last year, Kruijswijk lost the Giro lead in the 19th stage after a crash, eventually finishing fourth overall.
(Reporting by Julien Pretot; Editing by Amlan Chakraborty)
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