The sixth-seeded Czech needed just over an hour to down the first all-Japanese pair to reach a major final.
It was a long-overdue reward for Siniakova and Krejcikova, who captured the junior doubles title here in 2013.
They are the first all-Czech duo to capture the Roland Garros women's doubles title since Andrea Hlavackova and Lucie Hradecka in 2011.
(Reporting by Julien Pretot, editing by Pritha Sarkar)
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