The world and European champions return to action for the first time since losing the Confederations Cup final 3-0 to Brazil on June 30.
They do so with regulars such as Gerard Pique, Xavi and Sergio Busquets rested and replaced by fringe players and members of Spain's Under-21 side, who were crowned European champions in Israel in June.
The squad was released through the team's official Twitter feed @sefutbol.
Spain are on course to qualify for the World Cup finals in Brazil next year as they top Group I with 11 points from five games, a point ahead of France, with three left to play.
Their next qualifier is away to third-placed Finland in Helsinki on Sept 6.
Squad:
Goalkeepers: Iker Casillas (Real Madrid), Victor Valdes (Barcelona), Pepe Reina (Napoli)
Defenders: Alvaro Arbeloa (Real Madrid), Sergio Ramos (Real Madrid), Cesar Azpilicueta (Chelsea), Jordi Alba (Barcelona), Raul Albiol (Napoli), Inigo Martinez (Real Sociedad)
Midfielders: Javi Martinez (Bayern Munich), Andres Iniesta (Barcelona), Santi Cazorla (Arsenal), Isco (Real Madrid), Thiago Alcantara (Bayern Munich), Koke (Atletico Madrid)
Forwards: Jesus Navas (Manchester City), David Silva (Manchester City), Cesc Fabregas (Barcelona), Alvaro Negredo (Manchester City), Fernando Llorente (Juventus), Cristian Tello (Barcelona)
(Reporting by Mark Elkington, editing by Pritha Sarkar)
