Former NSW health minister John Della Bosca has confirmed he is quitting politics for a senior role in the non-government sector.
The Labor MP says he's resigning from the state's upper house to work with the National Disability and Carers Alliance.
He stepped down as health minister in September last year after a six months affair with a 26-year-old Sydney woman.
Earlier today his wife, disendorsed federal MP Belinda Neal, announced she won't be contesting her former federal seat of Robertson on the Central Coast as an independent.
Both were involved in the so-called Iguana affair over an argument in a restaurant in 2008.
The pair were considered to be a power couple within the NSW ALP, but the Iguanagate scandal tarnished both their reputations.
In the wake of the 2008 incident, Mr Della Bosca was also forced to stand aside as education minister as police investigated the alleged row involving him, his wife and staff at Iguanas restaurant and bar on the NSW Central Coast.
Police and the Director of Public Prosecutions (DPP) later said the pair had no case to answer over the incident.
After his resignation as Health Minister, Mr Della Bosca faced claims that he was mounting a challenge to former premier Nathan Rees' leadership.
Mr Della Bosca described his years in state parliament and within the Labor Party as a "privilege".
"I wish the Premier and the NSW Parliamentary Labor Party well and every success for the future. I would also like to publicly thank my colleagues and former staff for their support and advice over many years.
"I would also like to thank my family, in particular my wife Belinda."
Mr Della Bosca is the fourth Labor MP to leave parliament this year, heightening perceptions the NSW Labor government has reached its used-by date.
Former Penrith MP Karyn Paluzzano resigned after fronting an Independent Commission Against Corruption (ICAC) corruption inquiry in May, while Ian Macdonald also stood aside amid allegations he misused his ministerial travel entitlements.
Juvenile justice minister Graham West in June said he would resign at the March election because he had lost faith in politics.
Premier Kristina Keneally paid tribute to Mr Della Bosca's "proud parliamentary and ministerial record".
"I thank John for his tireless contribution to the people of NSW, the State Government and the Australian Labor Party," she said in a statement.
"I wish him all the best for his future endeavours in a key role in the non-government sector, working towards a national disability insurance scheme."
NSW Labor general secretary Sam Dastyari also thanked Mr Della Bosca for his service to the ALP.
"The Labor Party today thanks John Della Bosca for his years of dedicated work on behalf of the Labor movement," he said in a statement.
Mr Dastyari said the Upper House vacancy created by Mr Della Bosca's resignation would be filled before state parliament returns on August 31, but after the federal election.