"Palace are one of those teams that, when you look at their squad, nobody thought when we started that it would have fought relegation," Mazzarri told reporters in a news conference on Thursday.
"We will play them in their best moment as they come from two positive results.
"They've got an important fan base so it won't be easy. We go to the pitch knowing we cannot commit any mistakes."
Midfielder Daryl Janmaat and Nordin Amrabat are back in the Watford squad, while midfielder Etienne Capoue will have a chance to prove his fitness ahead of the match.
"Capoue has had a fever for two days and hasn't been training so we will check tomorrow," the Italian added.
Watford, who are 13th in the standings, have picked up 12 points from their 13 away games this season. Palace are 17th with 25 points, one point ahead of Hull City a spot below.
(Reporting by Hardik Vyas in Bengaluru; editing by Sudipto Ganguly)
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