Serbian world No.1 Novak Djokovic will take on Brazilian Joao Souza in the first round of the US Open and could face Spain's Rafael Nadal in the quarter-finals, while second-ranked Swiss Roger Federer will kick off his quest for a record sixth title in New York against Argentina's Leonardo Mayer.
Barring one or more upsets, Djokovic would square off in the tournament's final eight against Nadal, a former No.1 and two-time US Open champion who must get past promising Croatian teenager Borna Coric in his opening match.
The draw, unveiled on Thursday, puts Djokovic on course for a possible semi-final rematch against fourth-seeded Kei Nishikori of Japan, who upset the Serbian in last year's semifinals.
Nadal missed last year's US Open due to a wrist injury and comes into this year's event with low expectations after winning just two of nine matches thus far in 2015 against top 10 players.
Federer is expected to meet sixth-seeded Czech Tomas Berdych in the quarter-finals prior to a potential showdown in the semi-finals against Britain's Andy Murray, who has a difficult draw that includes a first-round match-up against talented Australian 20-year-old Nick Kyrgios and a possible last-eight clash with French Open champion Stanis Wawrinka.
Defending champion Marin Cilic of Croatia is seeded ninth and could face Spanish No. 7 seed David Ferrer in the round of 16 and then Nishikori in the quarterfinals.
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