The 37-year-old had battled to a 10-over-par 80 at Oak Hill Country Club on Thursday.
Donaldson, who won the second European Tour title of his career at the Abu Dhabi Championship earlier this year, was making his third appearance in the season's final major.
His best PGA Championship finish was a tie for seventh at Kiawah Island last year.
(Reporting by Mark Lamport-Stokes; Editing by Frank Pingue)
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