One of the widest investigations into autism has implicated several dozen genes, boosting the search for a diagnostic tool and new treatments, scientists said on Wednesday.
Mutations in these genes emerged in two studies that compared thousands of people with autism spectrum disorder against family members with or without ASD.
Many of the newly-found genetic variants are so-called spontaneous mutations, meaning they were not passed down from the parents.
The analysis was carried out by two teams, reporting separately in the science journal Nature.
ASD is a developmental disorder that has no cure. It leads to difficulties, sometimes cripplingly so, in social, emotional and communication skills.
The causes of the condition, though, are unclear.
Whether the risk comes from genes or the environment, or both - and if so, to what degree - are all fiercely debated.
Many of the newly-found genes are thought to be involved in the function of brain cells, including connections between neurons.
Spontaneous mutations, also called de novo mutations, are believed to occur early in foetal development, when errors in DNA code are transmitted when cells divide.
They have also been implicated among children born with cardiac defects, when their parents or brothers and sisters do not have congenital heart disease.
By eventually building a picture of DNA clues, doctors could help diagnose a child at risk of autism and boost chances of developing drugs to tackle the condition, the investigators said.
"We have a set of genes for which now, if people see a likely gene-disruptive mutation when sequencing a young child, there's a high risk of the child developing autism," said Evan Eichler of the Simons Foundation Autism Research Initiative, a US group.
"That, to my mind, is pretty powerful stuff," said Eichler.
"Recognising this early on may allow for earlier interventions, such as behavioural therapies, improving outcomes in children."
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