Dybala added his second four minutes after halftime, Higuain expertly holding up the ball before playing it into the path of the 24-year-old, who slotted it home right-footed.
The win put Juventus on 71 points, two ahead of Napoli with both sides having played 27 games.
Napoli, though, will regain the lead if they can beat Inter Milan in Sunday's late kickoff at the San Siro.
The sudden death last week of Fiorentina captain Davide Astori cast a pall over Sunday's proceedings in Serie A.
Many of last weekend's matches were postponed following his passing and this week's games began with both silence and applause as the 31-year-old Italian international was remembered.
In the day's early kickoff, Vitor Hugo scored the only goal as Fiorentina beat Benevento 1-0 at the Artemio Franchi stadium in a game filled with emotional tributes to Astori, who was buried on Thursday.
Lazio's Ciro Immobile scored both goals, including a superb backheel deep into stoppage time, to give his side a share of the spoils as they drew 2-2 away to Cagliari.
The brace puts Serie A top scorer Immobile on 24 goals from 24 games this season, six ahead of Inter's Mauro Icardi who has 18 in 22.
Having started the day second from bottom, Crotone hammered Sampdoria 4-1 at home to climb out of the relegation zone, with Marcello Trotta scoring twice and missing a penalty in an eventful outing for the home side.
Newcomers SPAL slipped into the bottom three following a 1-1 draw with fellow strugglers Sassuolo while Dutch midfielder Marten de Roon netted the winner seven minutes from time to give Atalanta a 1-0 victory at Bologna.
(Reporting by Philip O'Connor; Editing by Ian Chadband)
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