It means Jonathan Joseph, who scored a try against Wales, and George Kruis will make their first Twickenham starts.
Coach Stuart Lancaster's replacement bench is also unchanged with Sale fly half Danny Cipriani, who has not featured in a home international since 2008, again one of his backup options.
"It's always good to be able to name an unchanged team and to build some consistency," he said.
"We did the same last year after France heading into the Scotland game.
"Italy are going to be fired up. They always are when they come to Twickenham, especially after last week's loss to Ireland."
Italy were beaten 26-3 by Ireland.
England: 15-Mike Brown, 14-Anthony Watson, 13-Jonathan Joseph, 12-Luther Burrell, 11-Jonny May, 10-George Ford, 9-Ben Youngs; 8-Billy Vunipola, 7-Chris Robshaw (captain), 6-James Haskell, 5-George Kruis, 4-Dave Attwood, 3-Dan Cole, 2-Dylan Hartley, 1-Joe Marler
Replacements: 16-Tom Youngs, 17-Mako Vunipola, 18-Kieran Brookes, 19-Tom Croft, 20-Nick Easter, 21-Richard Wigglesworth, 22-Danny Cipriani, 23-Billy Twelvetrees
(Reporting by Martyn Herman; Editing by Ossian Shine)
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