Keaton Jennings' disappointing form continued with the England opening batsman removed for 17 on the opening morning of the fourth test against South Africa on Friday.
England, who had won the toss, were 1-67 at lunch at a blustery Old Trafford with captain Alastair Cook on 31 and partner Tom Westley on 19.
Left-hander Jennings, who has yet to reach a half-century in this series, edged Duane Olivier to keeper Quinton de Kock, with the moving ball on off stump again proving his downfall.
The 25-year-old had made an impressive start to Test cricket with century in his debut match against India in Mumbai in December.
But the hopes that he may quickly establish himself as Cook's opening partner have been brought into doubt by some shaky performances in this series although a 48 at the Oval ensured he kept his place.
The hosts lead 2-1 after a convincing win in the third Test at the Oval and are hoping for a first series win at home to the South Africans since 1998.
England kept the same side that won at the Oval but South Africa had to do without pacemen Vernon Philander and Chris Morris, both suffering from injuries.
Theunis de Bruyn and Olivier were the replacements.
