"Following an operation on his left knee on Tuesday, Jonny May will be ruled out for the remainder of the 2015-16 campaign," Gloucester said on their Twitter account on Thursday.
May was a member of England's 2015 World Cup squad and has 19 caps.
The Six Nations Championship starts next month.
(Reporting by Simon Jennings in Bengaluru; Editing by Tony Jimenez)
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