"Obviously, it was a big win last weekend and it's not an easy place to go but we went there (St Mary's) and played really well," McCarthy told the club's website.
"You saw how Man City played against Chelsea and it's going to be tough.
"They have won two games on the bounce but the mood in our camp is very good and we go into the game really confident," the 24-year-old added.
The midfielder said the atmosphere at Goodison Park could sway the game in Everton's favour.
"It's always a tough place to come, Goodison Park, and as long as the fans are behind us again this week, it will make things difficult for Man City.
"The fans are always massive for us. They travelled down in their numbers to Southampton and you could hear them from the first to the last minute," he said.
"Everyone worked really hard and hopefully now we can carry that into City," McCarthy added.
(Reporting by Simon Jennings in Bengaluru; editing by Sudipto Ganguly)
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