"I can tell you Mina is not available for the match. He is recovering from a small problem in his foot," Silva told a news conference.
Fellow new signing Richarlison, who struck twice against Wolves before going off with a cramp, has been cleared to play in the game at Goodison Park.
Midfielder Andre Gomes will not feature as he battles to shake off a hamstring injury while defender Kurt Zouma and playmaker Bernard are available to make their debuts.
"We've made new signings and I want there to be competition for each position. As a squad, it is the way I like to work. I like to have problems when making my decisions," Silva added.
Southampton began their campaign with a goalless draw against Burnley.
(Reporting by Shrivathsa Sridhar in Bengaluru; Editing by Christian Radnedge)
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