The former Manchester United full back left his role as England's assistant manager after the team's dismal Euro 2016 showing in June and was sacked after picking up just three wins in 16 La Liga games in charge of Valencia last season.
"I always say 'never say never' because my love of football is too great but I genuinely believe it will be very difficult for me to go back into coaching because of my commitment to so many different things," the 41-year-old Neville told Sky Sports television.
"I can't go back into coaching now in the short term, the next five years, and the reality of it is I don't want to. It could be that I'm no longer ever a coach in football but that's not a loss."
Neville, who has gone back to his old job as a Sky pundit and is also a co-owner of minor league side Salford City with his brother Phil and former United team mates Ryan Giggs, Paul Scholes and Nicky Butt, said he was disappointed to leave the FA.
"The FA and (former England manager) Roy Hodgson invested in me for four years and I'm the most experienced I've ever been, yet you get chucked overboard," he added.
"The reality is the investment has to come through defeat and victory. The pathway for young coaches cannot just be based on a run of defeats or a run of victories otherwise you are forever changing."
Former England defender Neville took full responsibility for Valencia's struggles during his time in charge of the Spanish top-flight outfit.
"There is nothing worse than hearing someone give reasons for why they've failed, of course sometimes there are reasons, but you have to take the blame yourself," he said.
"I can't go to Spain for four months, be coach of Valencia, and blame the fact there was a difficult dressing room, I didn't speak the language, we had bad luck and we missed some chances.
"Why? Because I knew I didn't speak the language before I went, I knew it was a difficult dressing room, I knew they had sacked lots of managers and I didn't deal with it," said Neville.
(Reporting by Ian Rodricks in Bengaluru; Editing by Tony Jimenez)
