Exciting progress on artificial 'ovaries'

Danish scientists have taken early steps towards developing an artificial ovary that could lead to improved fertility preservation treatments.

Scientists have made "exciting" progress in the development of artificial "ovaries" to help preserve women's fertility.

Immature eggs have been shown for the first time in a laboratory to survive on ovarian tissue which was removed from cancer patients before treatment and stripped of cells, researchers said.

It is hoped this engineered structure could be re-implanted into women and restore fertility after they have completed chemotherapy or radiotherapy.

Scientists from the Rigshospitalet in Copenhagen, proved the graft worked when using human tissue transplanted into mice.

Experts said the research, presented at the European Society of Human Reproduction and Embryology (ESHRE) annual meeting in Barcelona, "holds much promise for the future".

Many cancer treatments can damage the ovaries, stopping the body from producing eggs and meaning a woman cannot get pregnant.

Women dealing with a diagnosis can choose to have their eggs frozen, while some doctors may offer to remove or freeze all or part of an ovary so it can be transplanted back after treatment.

However, there is a small chance that grafted ovarian tissue could reintroduce cancer cells.

A "bio-engineered" ovary would reduce this risk, the research team from Rigshospitalet said.

Their experiments used ovarian tissue removed from women trying to preserve their fertility before cancer treatment.

The cells from the tissue were eliminated using chemicals, leaving behind a "bio-engineered scaffold" on which the early-stage egg-containing follicles were reseeded.

Dr Susanne Pors, who presented the research, said: "This is the first time that isolated human follicles have survived in a decellularised human scaffold and, as a proof-of-concept, it could offer a new strategy in fertility preservation without risk of malignant cell recurrence."


Share
2 min read

Published

Source: AAP


Share this with family and friends


Get SBS News daily and direct to your Inbox

Sign up now for the latest news from Australia and around the world direct to your inbox.

By subscribing, you agree to SBS’s terms of service and privacy policy including receiving email updates from SBS.

Download our apps
SBS News
SBS Audio
SBS On Demand

Listen to our podcasts
An overview of the day's top stories from SBS News
Interviews and feature reports from SBS News
Your daily ten minute finance and business news wrap with SBS Finance Editor Ricardo Gonçalves.
A daily five minute news wrap for English learners and people with disability
Get the latest with our News podcasts on your favourite podcast apps.

Watch on SBS
SBS World News

SBS World News

Take a global view with Australia's most comprehensive world news service
Watch the latest news videos from Australia and across the world