Chelsea have a 100 per cent record so far this season, with four wins from four, and lead the table with 12 points, five ahead of fifth-placed City.
Both suffered disappointing nights in the Champions League on Wednesday, however, Chelsea drawing at home to Schalke 04 and City losing 1-0 at Bayern Munich.
In between them are three unfancied teams who will be aiming to maintain their surprisingly strong starts to the season.
Aston Villa, regular under-achievers in recent years, are second but face a major test with a visit by Arsenal on Saturday (1500 BST) while Swansea City and Southampton, fourth and fifth respectively, meet at the Liberty Stadium, also on Saturday (1500 BST).
Louis van Gaal's Manchester United, who kick-started their campaign with a 4-0 win over QPR inspired by new signings Angel Di Maria, Ander Herrera and Daley Blind, travel to Leicester City on Sunday (1330 BST).
Lampard, 36, might have presumed he would never have to face his former Chelsea team mates when he signed for New York City in the summer.
But with the new franchise not entering MLS until next year, the midfielder was given the chance to make a quick return to English football with a loan deal to City.
The ex-England international made his competitive debut for the champions last weekend but he was withdrawn by Chilean boss Manuel Pellegrini at half-time after an unimpressive display.
EARLY BLOW
Yaya Toure's possible return to the City midfield means Lampard might have to settle for a bit-part role as Pellegrini and Mourinho seek to register an early blow in the title race they are expected to dominate.
Diego Costa, the Spain striker with seven goals in four games so far for his new club, will likely be instrumental again in Chelsea's chances of success.
At Villa Park, a Villa team galvanised by Roy Keane's appointment as Paul Lambert's number two - and full of confidence after a 1-0 win at Liverpool last weekend - face an Arsenal side outplayed by Borussia Dortmund in the Champions League in midweek.
Danny Welbeck is still looking for his first goal for the Gunners since his 16 million pounds move from Manchester United, and manager Arsene Wenger has to contend with more injury problems after Jack Wilshere turned his ankle against Dortmund.
Saturday's game at St James' Park between Newcastle United and Hull City (1500 BST) could be pivotal for both teams.
Newcastle manager Alan Pardew is fighting for his job, according to reports, with his team bottom of the table with two points from a possible 12.
Owner Mike Ashley has given Pardew his support for now, but if 10th-placed Hull inflict another defeat on the Magpies, it could signal the end of the manager's reign - especially as Hull boss Steve Bruce has been tipped by some in the British media as Pardew's potential successor.
In other games this weekend, Liverpool travel to West Ham United on Saturday (1730 BST), Tottenham host West Bromwich Albion on Sunday (1330 BST), and Everton and Crystal Palace meet at Goodison Park on Sunday (1600 BST).
(Writing by Stephen Wood, editing by Steve Tongue)
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