Federal Labor frontbencher Mark Butler is set to lose his South Australian seat after it was recommended for abolition ahead of the next national election.
SA will lose one seat in the redistribution, taking the number of House of Representatives electorates in the state to 10.
Voters in Mr Butler's seat of Port Adelaide will mainly move to his Labor colleague Nick Champion's seat of Wakefield, which will be renamed Spence.
Mr Butler, who has held the seat since 2007, noted it was a draft recommendation by the Australian Electoral Commission but was "disappointed" in the proposal.
"This seat is deeply entrenched in the local community, with a proud and long history," he said.
"I will be looking at all my options as I continue to serve my community and as we await a final decision by the commission."
It is understood Mr Champion intends to contest preselection in Spence.
The redistribution spares coalition frontbencher Christopher Pyne, who was tipped to lose his seat.
Instead, Mr Pyne now looks likely to pick up votes, with the inner city suburbs of Norwood and Toorak Gardens added to his electorate.
Electoral commissioner Tom Rogers said a seat had to be abolished, but nine of the 11 eleven seats had too many or too few voters.
"The committee believes the proposal caters for differing rates of expected growth and decline across the state while improving communities of interest where possible and using strong, identifiable features as boundaries," Mr Rogers said in a statement on Friday.
The new seat is named after a prominent advocate for female suffrage and electoral reform Catherine Helen Spence.
ABC election analyst Antony Green said Hindmarsh and Spence would become much safer for Labor, while Sturt had been "barely touched".
Hindmarsh would shift from being an ultra-marginal seat, held by a 0.6 per cent margin, to a safe Labor seat with a margin of around 8.2 per cent.
Labor's margin in Spence would be around 18 per cent.
Nick Xenophon Team MP Rebekha Sharkie's prospects of holding Mayo against a Labor or Liberal challenge would be harder under the new boundaries.
Objections can still be made against the proposed boundary changes, with the final redistributions announced by July.
