"Unfortunately I won't be able to play at Wimbledon because of an injury to my elbow," the 33-year-old, who has played in 50 consecutive grand slam tournaments since the 2003 Australian Open, said on his Twitter page.
"It's time to get better as quickly as possible."
Ferrer, who was seeded eighth, had been due to face Briton James Ward in the first round but will now be replaced in the draw by lucky loser from qualifying Luca Vanni of Italy.
Ferrer had been seeded to play fellow Spaniard Rafa Nadal in the quarter-finals, a stage he has reached twice in his career at the grasscourt tournament.
(Reporting by Martyn Herman; editing by Toby Davis)
