Denmark's Lasse Jensen carded a 68 to finish runner-up on 13-under for his best result on the European Tour. Belgium's Nicolas Colsaerts was in third place a further shot behind after a final round of 70.
Fitzpatrick's second European Tour title, after last year's British Masters, consolidated his fourth place standing in the Ryder Cup European points list.
The top four Europeans qualify for the Sept. 30 competition against the United States in Hazeltine, Minnesota.
"It was a great final day for me and I managed to hold on to my lead fairly well and get the win. I felt like today was the round were I would be under the most pressure," said Fitzpatrick, who bogeyed the final hole.
"I'm a million miles ahead of schedule. It's been a tough past few weeks and all of a sudden you turn up and pick up a win. That's golf and I've seen it a lot this year," said Fitzpatrick.
Sweden's Henrik Stenson had the lowest round of the day at Bro Hof Slott with a closing 66 to finish in a tie for fourth with local favourite Bjorn Hellgren (67) at 10 under.
(Reporting by Alan Baldwin, editing by Ken Ferris)
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