Police say the men, aged between 19 and 21, turned themselves in around 9pm on Tuesday.
A 47-year-old woman has alleged she was raped by five men after being lured into a laneway at South Yarra in the early hours of Sunday morning.
The woman says her legs were bound with tape during the attack. She has told police she ripped off the tape and ran naked to raise the alarm.
Police say the men have been interviewed and released pending further inquiries.
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