"Over the past few months a number of friends and family have raised concerns surrounding my health," Weir said in a statement.
"I think then, that on the day set to help raise awareness of the condition, I should confirm that I too have motor neuron disease," the 46-year-old added.
"I should like to take this opportunity to thank the National Health Service in recognising then diagnosing this, as yet, incurable disease."
Scottish Rugby's Chief Operating Officer Dominic McKay said in a statement: "Our thoughts are with Doddie and his family at this time. Doddie gave distinguished service to the national team for 10 years and has been a terrific ambassador for our sport."
(Reporting by Hardik Vyas in Bengaluru, editing by Ed Osmond)
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