Chilean Luis Ayala (49) and Argentinian Ricardo Cano (30) were almost three years older when they met in the first round of the 1982 Chile Open, with the latter recording a 6-1 6-2 win.
Karlovic has beaten Haas in four of their six meetings, starting with another Rome Masters first round showdown in 2004. They last faced each other in the first round of the Rogers Cup eight years ago.
(Reporting by Aditi Prakash in Bengaluru; Editing by John O'Brien)
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