"We will not renew the contract with Napoli under any circumstances with this clause," Nicolas Higuain told Argentina's Radio Continental.
"The president of the club always insists on the buyout clause in case of a possible transfer of Gonzalo and we have our right not to renew the contract," he added.
Argentina international Higuain has been linked with a move to Spain's Atletico Madrid and several Premier League clubs.
The 28-year-old was Serie A's top scorer last season with 36 goals in 35 league games.
(Reporting by Silvia Recchimuzzi and Anna Jaworska-Guidotti in Gdynia, additional reporting by Pawel Goraj, editing by Ed Osmond)
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