Nearly three years after undergoing brain surgery, Holmes completed the long journey back to the top when he carded a closing round one-under-par 71 at Quail Hollow.
The 32-year-old from Kentucky sank a three-foot bogey at the last to secure his third victory on the PGA Tour, and his first since 2008.
Holmes finished at 14-under 274, while compatriot Jim Furyk shot a 65 to vault into second place on 13-under.
(Reporting by Andrew Both. Editing by Gene Cherry)
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